1,1,3,3-Tetramethoxypropane (Malonaldehyde Tetramethyl Acetal, 99%)

Description Chemical Specifications   Property Details Chemical Name 1,1,3,3-Tetramethoxypropane Synonyms Malonaldehyde tetramethyl acetal Molecular Formula C7H16O4 Molecular Weight 164.20 g/mol CAS Number 102-52-3 Purity ≥ 99% Appearance Clear, colorless liquid Boiling Point ~169–171°C Density ~1.06 g/mL at 25°C Solubility Miscible with most organic solvents Odor Mild, ether-like Stability Stable under neutral and basic conditions Description and Chemical Profile 1,1,3,3-Tetramethoxypropane is the tetramethyl acetal derivative of malonaldehyde, which makes it a stable storage form of the highly reactive and unstable malonaldehyde. Under acidic hydrolysis, it releases malonaldehyde (propanedial), a dialdehyde known for its role in biochemical and lipid peroxidation studies. This makes tetramethoxypropane a preferred reagent in analytical chemistry, especially in assays measuring lipid peroxidation products such as thiobarbituric acid reactive substances (TBARS). Applications 1. Biochemical & Medical Research Tetramethoxypropane is used extensively in TBARS assays to quantify malondialdehyde (MDA) — a biomarker of oxidative stress and lipid peroxidation in biological systems. It is often employed to create calibration standards in clinical and biomedical research. 2. Organic Synthesis As a masked dialdehyde, it acts as a precursor to reactive carbonyl compounds, offering greater control in multi-step reactions. It’s particularly valuable in synthesis strategies involving aldehyde protection, nucleophilic additions, or cross-linking reactions. 3. Polymer & Material Science The compound’s reactivity profile also makes it suitable for specialized applications in resin modification, polymer cross-linking, and material engineering, where controlled release of malonaldehyde is advantageous. Safety and Handling While 1,1,3,3-Tetramethoxypropane is generally considered stable and less volatile than malonaldehyde itself, it should be handled with standard laboratory precautions: Store in a cool, dry, and well-ventilated area Keep away from acids and oxidizing agents Use appropriate personal protective equipment (gloves, goggles, lab coat) In case of contact with acid, it may hydrolyze and release irritant vapors Always refer to the Safety Data Sheet (SDS) for detailed guidance. Conclusion 1,1,3,3-Tetramethoxypropane (Malonaldehyde Tetramethyl Acetal, 99%) is a valuable compound in both scientific research and industrial synthesis, offering a stable and high-purity solution for working with reactive dialdehydes. Its role in lipid peroxidation assays, along with its effectiveness as a synthetic intermediate, makes it an indispensable tool in modern chemistry labs. Its reliable performance, safety, and versatility continue to make it the compound of choice for precision applications.